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PF-06447475

PF-06447475

Item no.	HY-12477-5mg
Manufacturer	MedChem Express
CASRN	1527473-33-1
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 25 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Neuroinflammation Neural Mitochondrial Function Inhibitors & Compound Libraries Small Molecules Calcium Binding Protein Markers
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.94
Formula	C17H15N5O
Citations	[1]Henderson JL, et al. Discovery and preclinical profiling of 3-[4-(morpholin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile (PF-06447475), a highly potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor. J Med Chem. 2015 Jan 8;58(1):419-32. [2]Mendivil-Perez M, et al. Neuroprotective Effect of the LRRK2 Kinase Inhibitor PF-06447475 in Human Nerve-Like Differentiated Cells Exposed to Oxidative Stress Stimuli: Implications for Parkinson's Disease. Neurochem Res. 2016 Oct;41(10):2675-2692. [3]Daher JP, et al. Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. J Biol Chem. 2015 Aug 7;290(32):19433-44.
Smiles	N#CC1=CC=CC(C2=CNC3=NC=NC(N4CCOCC4)=C32)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1527473-33-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	LRRK2
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	305.33
Product Description	PF-06447475 is a highly potent, selective and brain penetrant LRRK2 inhibitor with an IC50 of 3 nM.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 60 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy
Clinical information	No Development Reported

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HY-12477-5mg-safety-datasheet.pdf