ANA-12

Item no.	HY-12497-10mM
Manufacturer	MedChem Express
CASRN	219766-25-3
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Metabolism Diabetes Glucose Homeostasis Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Cazorla M, et al. Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice. J Clin Invest. 2011 May;121(5):1846-57.\|[2]Zhang JC, et al. Comparison of ketamine, 7,8-dihydroxyflavone, and ANA-12 antidepressant effects in the social defeat stress model of depression. Psychopharmacology (Berl). 2015 Dec;232(23):4325-35.\|[3]Vassoler FM, et al. Epigenetic inheritance of a cocaine-resistance phenotype. Nat Neurosci. 2013 Jan;16(1):42-7.\|[4]Fang X, et al. Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury. Eur Arch Psychiatry Clin Neurosci. 2018 Jun 7.
Smiles	O=C(C1=CC2=CC=CC=C2S1)NC3=CC=CC=C3C(NC4C(NCCCC4)=O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	219766-25-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Trk Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	407.49
Product Description	ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 7.69 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Neuronal Signaling; Protein Tyrosine Kinase/RTK
Clinical information	No Development Reported
Isoform	TrkB

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HY-12497-10mM-safety-datasheet.pdf