cGAMP

Item no.	HY-12512-1mg
Manufacturer	MedChem Express
CASRN	849214-04-6
Amount	1 mg
Quantity options	100 mg 10 mMx1 mL 10 mg 1 ea 1 mg 25 mg 500 ug 5 mg
Category	Food Safety Allergenes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.22
Citations	[1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.\|[2]Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150.\|[3]Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18.\|[4]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4. ACS Nano. 2025 Feb 23.\|Biochem Pharmacol. 2023 May 19;213:115618.\|Biomaterials. 2023 Mar 31, 122104.\|Cell Death Differ. 2025 Feb 12.\|Cell Rep. 2023 Apr 5;42(4):112328.\|Chem Eng J. 2022: 140190.\|Chin Herb Med. 2024 Jul.\|J Nanobiotechnology. 2022 Jan 6;20(1):23.\|Nat Commun. 2024 Dec 4;15(1):10543.\|Nat Commun. 2024 Jul 18;15(1):6053.\|Nat Commun. 2024 Jul 23;15(1):6193.\|Sci China Life Sci. 2024 Aug 22.\|bioRxiv. 2020 Jul.\|Patent. US20210017607A1.
Smiles	O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Cyclic GMP-AMP,3',3'-cGAMP
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	STING
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	674.41
Product Description	cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	H2O: 180 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-12512-1mg-safety-datasheet.pdf