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3,5-Diiodothyropropionic acid

3,5-Diiodothyropropionic acid

Item no.	HY-126236-10mg
Manufacturer	MedChem Express
CASRN	1158-10-7
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Food Safety Inhibitors & Compound Libraries Small Molecules Food Additives Preservatives
Type	Inhibitors
Specific against	other
Purity	99.20
Citations	[1]Pennock GD, et al. Cardiac effects of 3,5-diiodothyropropionic acid, a thyroid hormone analog with inotropic selectivity. J Pharmacol Exp Ther. 1992 Oct;263(1):163-9.\|[2]Liu Y, et al. Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function. Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1551-7. \|[3]Maitra N, et al. Regulation of gene expression in rats with heart failure treated with the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) and the combination of DITPA and captopril. J Cardiovasc Pharmacol. 2007 Nov;50(5):526-34. \|[4]Mousa SA, et al. Proangiogenesis action of the thyroid hormone analog 3,5-diiodothyropropionic acid (DITPA) is initiated at the cell surface and is integrin mediated. Endocrinology. 2006 Apr;147(4):1602-7.
Smiles	O=C(O)CCC1=CC(I)=C(OC2=CC=C(O)C=C2)C(I)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1158-10-7
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	Thyroid Hormone Receptor
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	510.06
Product Description	3, 5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively. 3, 5-Diiodothyropropionic acid promotes angiogenesis in 3-D human dermal microvascular endothelial cell sprouting assay. 3, 5-Diiodothyropropionic acid prevents myocardial arteriolar loss in thyroidectomized rats and enhances cardiac energy-generating capacity in postinfarction heart failure rats. 3, 5-Diiodothyropropionic can be used in studies related to angiogenesis and heart failure[1][2][3][4].
Manufacturer - Research Area	Cardiovascular Disease; Endocrinology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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