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Rhosin (hydrochloride)

Rhosin (hydrochloride)

Manufacturer	MedChem Express
Category	Cell Biology Cytoskeleton Inhibitors & Compound Libraries Small Molecules small GTPases Rho Subfamily
Type	Inhibitors
Specific against	other
Amount	10 mg
Item no.	HY-12646-10mg
Targets	Ras; Apoptosis
CASRN	1281870-42-5
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Rhosin hydrochloride is a potent, specific RhoA subfamily Rho GTPases inhibitor. Rhosin hydrochloride specifically binds to RhoA to inhibit RhoA-GEF interaction with a Kd of ~ 0.4 uM, and does not interact with Cdc42 or Rac1, nor the GEF, LARG. Rhosin hydrochloride induces cell apoptosis[1][2]. Rhosin hydrochloride promotes stress resiliency through enhancing D1-MSN plasticity and reducing hyperexcitability[3].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	394.86
Clinical_Information	No Development Reported
Manufacturers Research_Area	Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic)\|H2O : 16.67 mg/mL (ultrasonic)
Manufacturers Target	Apoptosis; Ras
Pathway	Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Manufacturers Product type	Reference compound

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HY-12646-10mg-safety-datasheet.pdf