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K-7174 (dihydrochloride)

K-7174 (dihydrochloride)

Item no.	HY-12743A-10mM
Manufacturer	MedChem Express
CASRN	191089-60-8
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	98.72
Citations	[1]Umetani M, et al. A novel cell adhesion inhibitor, K-7174, reduces the endothelial VCAM-1 induction by inflammatory cytokines, acting through the regulation of GATA. Biochem Biophys Res Commun. 2000 Jun 7;272(2):370-4.\|[2]Imagawa S, et al. A GATA-specific inhibitor (K-7174) rescues anemia induced by IL-1beta, TNF-alpha, or L-NMMA. FASEB J. 2003 Sep;17(12):1742-4.\|[3]Kikuchi J, et al. The novel orally active proteasome inhibitor K-7174 exerts anti-myeloma activity in vitro and in vivo by down-regulating the expression of class I histone deacetylases. J Biol Chem. 2013 Aug 30;288(35):25593-602. Adv Sci (Weinh). 2025 Mar 5:e2404311.\|Biomaterials. 2021, 120967.\|bioRxiv. 2019 Sep.\|Cell Rep Med. 2022 Mar 15;3(3):100561.\|Department of Molecular Medicine and Biopharmaceutical Sciences. 2020 May.\|FASEB J. 2020 Mar;34(3):4462-4481.\|J Assist Reprod Genet. 2024 Aug 15.\|J Clin Invest. 2024 Aug 15:e175023.\|Adv Healthc Mater. 2024 Jul;13(18):e2304439.\|Adv Sci (Weinh). 2025 Mar 5:e2404311.\|Biochem Genet. 2024 Dec 16.\|Brain Res. 2022.\|FEBS Open Bio. 2020 Sep;10(9):1880-1890.\|Research Square Preprint. 2020 Dec.
Smiles	COC1=C(OC)C(OC)=CC(/C=C/CCCN2CCN(CCC/C=C/C3=CC(OC)=C(OC)C(OC)=C3)CCC2)=C1.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	191089-60-8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Apoptosis; Proteasome
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	641.67
Product Description	K-7174 dihydrochloride is an orally active proteasome and GATA inhibitor. K-7174 dihydrochloride is a cell adhesion inhibitor. K-7174 dihydrochloride induces cell apoptosis. K-7174 dihydrochloride shows antitumor activities, it can be used for the research of cancer[1][2][3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 100 mg/mL (ultrasonic)\|H2O: 15 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Apoptosis; Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-12743A-10mM-safety-datasheet.pdf