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Genz-123346 (free base)

Genz-123346 (free base)

Item no.	HY-12744-10mg
Manufacturer	MedChem Express
CASRN	491833-30-8
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.57
Citations	[1]Zhao H, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes. 2007 May;56(5):1210-8.\|[2]Chai L, et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol. 2011 Mar;38(3):701-11.\|[3]Shen W, et al. Inhibition of glucosylceramide synthase stimulates autophagy flux in neurons. J Neurochem. 2014 Jun;129(5):884-94\|[4]Natoli TA, et al. Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models. Nat Med. 2010 Jul;16(7):788-92. Faculty of Life Sciences, University College London. 2019 Oct.\|Front Pharmacol. 2024 Oct 1:15:1409625.\|Nat Cell Biol. 2025 Feb 21.\|PeerJ. September 14, 2021.\|Am J Respir Crit Care Med. 2019 Nov 1;200(9):1113-1125.
Smiles	CCCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	491833-30-8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Glucosylceramide Synthase (GCS)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	418.57
Product Description	Genz-123346 free base is an orally available inhibitor of glucosylceramide synthase. Genz-123346 blocks the conversion of ceramide to glucosylceramide (GL1) and inhibits GM1 with an IC50 of 14 nM[1].
Manufacturer - Research Area	Metabolic Disease; Cancer
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	Neuronal Signaling
Clinical information	No Development Reported

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HY-12744-10mg-safety-datasheet.pdf