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MD2-TLR4-IN-1

MD2-TLR4-IN-1

Item no.	HY-128598-25mg
Manufacturer	MedChem Express
CASRN	2249801-12-3
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Obesity Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	98.16
Citations	[1]Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.
Smiles	ClC1=C(C(NC2=CC(C(C3=CC=C(NC=C4)C4=C3)=NN5)=C5C=C2)=O)C(Cl)=CC=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	2249801-12-3
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	NF-κB; Toll-like Receptor (TLR)
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	421.28
Product Description	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex antagonist. MD2-TLR4-IN-1 inhibits Lipopolysaccharides (HY-D1056) (LPS)-induced expression of TNF-α and IL-6 in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. MD2-TLR4-IN-1 can be used for the study of acute lung injury (ALI)[1].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 83.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Immunology/Inflammation; NF-κB
Isoform	TLR4
Clinical information	No Development Reported

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HY-128598-25mg-safety-datasheet.pdf