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Methylnitronitrosoguanidine

Methylnitronitrosoguanidine

Item no.	HY-128612-100mg
Manufacturer	MedChem Express
CASRN	70-25-7
Amount	100 mg
Quantity options	100 mg 10 mMx1 mL 1 g 50 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]Slapikoff SA, et, al. Comparison of toxicity and mutagenicity of methylnitrosourea, methylnitronitrosoguanidine and ICR-191 among human lymphoblast lines. Mutat Res. 1980 May;70(3):365-71.\|[2]Zhang L, Jia B, et, al. Corilagin induces apoptosis and inhibits HMBG1/PI3K/AKT signaling pathways in a rat model of gastric carcinogenesis induced by methylnitronitrosoguanidine. Environ Toxicol. 2022 May;37(5):1222-1230.\|[3]Bignami M, et al. Temporal dissociation in the exposure times required for maximal induction of cytotoxicity, mutation, and transformation by N-methyl-N'-nitro-N-nitrosoguanidine in the BALB/3T3 ClA31-1-1 cell line. Cancer Res. 1984 Jun;44(6):2452-7.\|[4]Wen JX, et al. Therapeutic effects and potential mechanism of dehydroevodiamine on N-methyl-N'-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis. Phytomedicine. 2021 Oct;91:153619.\|[5]Ghoneum MH, et al. Hydroferrate fluid, MRN-100, provides protection against chemical-induced gastric and esophageal cancer in Wistar rats. Int J Biol Sci. 2015 Jan 28;11(3):295-303.
Smiles	N=C(N[N+]([O-])=O)N(C)N=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	MNNG
Similar products	70-25-7
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA Alkylator/Crosslinker
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	147.09
Product Description	Methylnitronitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. Methylnitronitrosoguanidine can as a carcinogen and mutagen[1][2]. 50% water content, specifications are based on dry weight.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 116.67 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	No Development Reported

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HY-128612-100mg-safety-datasheet.pdf