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2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt)

2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt)

Item no.	HY-12885B-25mg
Manufacturer	MedChem Express
CASRN	1638750-96-5
Amount	25 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Molecular Targets for Neuroscience Targets for Rodent Neurosciences By Cell Type Melanoma Inhibitors & Compound Libraries Small Molecules By Organ Bone Cancer Cytoskeleton Markers
Type	Inhibitors
Specific against	other
Purity	99.89
Citations	[1]Corrales L, et al. Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Rep. 2015 May 19;11(7):1018-30. Biomaterials. 2018 May;163:67-75. \|bioRxiv. 2024 Jan 23.\|bioRxiv. 2024 September 20.\|bioRxiv. October 23, 2021.\|Cancer Cell. 2020 Mar 16;37(3):289-307.e9. \|Commun Biol. 2021 Apr 22;4(1):497.\|Eur J Med Chem. 2022 Sep 28;243:114796.\|J Clin Invest. 2024 Mar 19:e176748.\|J Interferon Cytokine Res. 2025 Jan 8.\|Mater Today Bio. 2024 Mar 11, 101018.\|Nat Commun. 2022 May 31;13(1):3022.\|Nature. 2023 Apr;616(7958):806-813.\|Patent. US20210322327A1.\|Patent. US20220162199A1.\|Patent. US20220395465A1.\|PLoS One. 2020 Sep 10;15(9):e0237743.\|University of Pittsburgh. School of Medicine. 2021 May 14.\|ACS Appl Mater Interfaces. 2025 Jan 23.\|Acta Crystallogr D Struct Biol. 2020 Sep 1;76(Pt 9):889-898. \|bioRxiv. 2024 May 14.\|Cancer Cell. 2023 Jun 12;41(6):1073-1090.e12.\|Cancer Res Commun. 2023 Dec 26.\|Cell Commun Signal. 2025 Feb 19;23(1):99.\|Cell Mol Gastroenterol Hepatol. 2021 Feb 3;S2352-345X(21)00024-2.\|Environ Int. 2020 Oct;143:105949.\|Eur J Med Chem. 2023 Feb 4;250:115184.\|Front Immunol. 2021 Jul.\|Front Immunol. 2023 Oct 13:14:1258691.\|Immunology. 2022 Jul 20.\|Inflamm Res. 2023 Jul 11.\|Int J Mol Sci. 2023 Dec 20, 25(1), 86.\|J Control Release. 2025 Jan 14:379:327-343.\|J Immunother Cancer. 2019 Sep 18;7(1):252. \|J Neuroinflammation. 2023 Apr 30;20(1):101.\|Mol Cell Biochem. 2021 Feb;476(2):1015-1024.\|Nat Commun. 2023 Mar 13;14(1):1390.\|Nat Commun. 2023 Sep 18;14(1):5666.\|Nat Commun. 2024 Nov 15;15(1):9934.\|Nat Nanotechnol. 2021 Sep 30.\|Neuron. 2022 Nov 4;S0896-6273(22)00961-8.\|Patent. US20200146975A1\|Patent. US20210205468A1.\|Patent. US20230062932A1.\|Purdue University. 2024 Jul 20.\|Research Square Preprint. 2022 Feb.\|Research Square Preprint. 2022 Jan.\|Research Square Preprint. 2024 Apr 5.\|University of Toronto. 2023 Jun.\|Wayne State University. 2024.\|Acta Pharm Sin B. 2024 Jun 11.\|Adv Sci (Weinh). 2024 Nov 19:e2407222.\|Adv Sci (Weinh). 2025 Feb 25:e2414110.\|bioRxiv. 2024 September 07.\|Cancer Cell. 2024 May 13;42(5):850-868.e9.\|Cell Death Dis. 2022 Jul 28;13(7):653.\|Chem Biodivers. 2024 Jul 12:e202401253.\|Genes Dis. 2024 Sep 15.\|J Autoimmun. 2024 Apr 30:146:103232.\|J Immunother Cancer. 2024 Oct 14;12(10):e009803.\|Nat Cell Biol. 2024 Jul 30.\|Nat Commun. 2023 Oct 2;14(1):6132.\|Sci China Life Sci. 2024 Aug 22.
Smiles	O[C@H]1[C@@H](O[P@@](OC[C@H]2O[C@@H](N3C(N=CN=C4N)=C4N=C3)[C@H](O)[C@@H]2O5)(S)=O)[C@H](N6C(N=CN=C7N)=C7N=C6)O[C@@H]1CO[P@]5(S)=O.N.N
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ADU-S100 (ammonium salt),MIW815 (ammonium salt),ML RR-S2 CDA (ammonium salt)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	STING
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	724.60
Product Description	2’3’-c-di-AM(PS)2 (Rp, Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity[1].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO: 15 mg/mL (ultrasonic; warming)\|H2O: 100 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Immunology/Inflammation
Clinical information	Phase 2

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-12885B-25mg-safety-datasheet.pdf