Comparison

Quizartinib European Partner

Manufacturer MedChem Express
Category
Type Inhibitors
Specific against other
Amount 100 mg
Item no. HY-13001-100mg
Targets FLT3
CASRN 950769-58-1
eClass 6.1 30220300
eClass 9.0 32160605
Available
Product Description
Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].
StorageTemperature
-20°C, 3 years; 4°C, 2 years (Powder)
Shipping
Room Temperature
Manufacturers Applications
Cancer-Kinase/protease
MolecularWeight
560.67
Clinical_Information
Launched
Manufacturers Research_Area
Cancer
Solubility
DMF : 10 mg/mL (ultrasonic)|DMSO : ≥ 33 mg/mL
Pathway
Apoptosis; Autophagy; PROTAC; Protein Tyrosine Kinase/RTK
Manufacturers Product type
Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 mg
Available: In stock
available

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