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PF-3758309

PF-3758309

Manufacturer	MedChem Express
Category	Neuroscience Targets for Rodent Neurosciences Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	5 mg
Item no.	HY-13007-5mg
Targets	PAK; Apoptosis
CASRN	898044-15-0
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation[1][2][3].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	490.62
Clinical_Information	Phase 1
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL
Manufacturers Target	Apoptosis; PAK
Isoform	PAK1; PAK2; PAK3; PAK4; PAK5; PAK6
Pathway	Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	Reference compound

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-13007-5mg-safety-datasheet.pdf