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MK-0354

MK-0354

Item no.	HY-13008-5mg
Manufacturer	MedChem Express
CASRN	851776-28-8
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Metabolism Diabetes Glucose Homeostasis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.73
Citations	[1]Semple G, et al. 3-(1H-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice. J. Med. Chem., 2008, 51 (16), pp 5101-5108\|[2]Lai E1, et al. Effects of a niacin receptor partial agonist, MK-0354, on plasma free fatty acids, lipids, and cutaneous flushing in humans. J Clin Lipidol. 2008 Oct;2(5):375-383.
Smiles	C12=C(CCC2)C(C3=NN=NN3)=NN1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	851776-28-8
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	GPR109A
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	176.18
Product Description	MK-0354 is a specific GPR109a receptor agonist, acting on hGPR109a/mGPR109a, with EC50 of 1.65 μM and 1.08 μM respectively, and has no effect on GPR109b.
Manufacturer - Research Area	Cardiovascular Disease
Solubility	DMSO: ≥ 36 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

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HY-13008-5mg-safety-datasheet.pdf