RepSox

Manufacturer	MedChem Express
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer S100 Calcium Binding Protein B Markers
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	10mM/1mL
Item no.	HY-13012-10mM
Targets	TGF-β Receptor
CASRN	446859-33-2
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes[1][2].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-Kinase/protease
MolecularWeight	287.32
Clinical_Information	No Development Reported
Manufacturers Research_Area	Metabolic Disease
Solubility	DMSO : 33.33 mg/mL (ultrasonic)
Manufacturers Target	Organoid; TGF-β Receptor
Isoform	ALK5
Pathway	Stem Cell/Wnt; TGF-beta/Smad
Manufacturers Product type	Reference compound

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HY-13012-10mM-safety-datasheet.pdf