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Fostamatinib Disodium

Fostamatinib Disodium

Item no.	HY-13038-10mg
Manufacturer	MedChem Express
CASRN	1025687-58-4
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Oncology Neuroscience Metabolism Cholesterol & Lipid Metabolism Neural Signaling Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.88
Citations	[1]Stephen P McAdoo, et al. Fostamatinib Disodium. Drugs Future. 2011;36(4):273.\|[2]Sylvia Braselmann, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008.\|[3]Hoon-Suk Cha , et al. A novel spleen tyrosine kinase inhibitor blocks c-Jun N-terminal kinase-mediated gene expression in synoviocytes. J Pharmacol Exp Ther. 2006 May;317(2):571-8. Hematol Oncol. 2025 Mar;43(2):e70058.\|Blood Cancer J. 2014 Aug 22;4(8):e240. \|Blood. 2022 Nov 15.\|BMC Med. 2024 Mar 5;22(1):96.\|Cancer Cell. 2014 Feb 10;25(2):226-42.\|EMBO J. 2021 Apr 28;e106771.\|Gene. 2020 Jun 20;744:144608.\|Mol Divers. 2025 Mar 14.\|Nat Med. 2018 Feb;24(2):232-238.\|Oxid Med Cell Longev. 2021 Feb 26.\|Patent. US20230288401A1.\|Research Square Print. 2023 Mar 17.\|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
Smiles	COC1=CC(NC2=NC=C(C(NC3=NC(N4COP(O[Na])(O[Na])=O)=C(C=C3)OC(C)(C)C4=O)=N2)F)=CC(OC)=C1OC
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	R788(Disodium)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	FLT3; Syk
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	624.42
Product Description	Fostamatinib Disodium (R788 Disodium) is the oral proagent of the active compound R406[1]. R406 is an orally available and competitive Syk/FLT3 inhibitor with a Ki of 30 nM and an IC50 of 41 nM[2]. R406 also inhibits Lyn (IC50=63 nM) and Lck (IC50=37 nM)[3].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO: 20.83 mg/mL (ultrasonic; warming; heat to 60°C)\|H2O: ≥ 1 mg/mL
Manufacturer - Pathway	Protein Tyrosine Kinase/RTK
Clinical information	Launched

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HY-13038-10mg-safety-datasheet.pdf