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UK-383367

UK-383367

Item no.	HY-13102-5mg
Manufacturer	MedChem Express
CASRN	348622-88-8
Amount	5 mg
Quantity options	10 mM/1 mL 10 mg 1 mg 25 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.92
Formula	C15H24N4O4
Citations	[1]Allan GA, et al. Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica. 2006 May;36(5):399-418. [2]Mi Bai, et al. BMP1 inhibitor UK383,367 attenuates renal fibrosis and inflammation in CKD. Am J Physiol Renal Physiol. 2019 Dec 1;317(6):F1430-F1438. [3]Eugenia C Salcedo, et al. Global Protease Activity Profiling Identifies HER2-Driven Proteolysis in Breast Cancer. ACS Chem Biol. 2021 Apr 16;16(4):712-723.
Smiles	NC(C1=NOC([C@H](CCCC2CCCCC2)CC(NO)=O)=N1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	348622-88-8
Shipping condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Targets	Procollagen C Proteinase
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	324.38
Product Description	UK-383367 is an orally available pro-collagen C-protease inhibitor (BMP-1) with an IC50 value of 44 nM. UK-383367 can reduce renal fibrosis and inflammation in chronic kidney disease (CKD) and may be used to study postoperative skin scarring[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO : 65 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Metabolic Enzyme/Protease
Clinical information	No Development Reported

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HY-13102-5mg-safety-datasheet.pdf