« Back
Home /
CGS 21680 (Hydrochloride)

CGS 21680 (Hydrochloride)

Item no.	HY-13201A-10mg
Manufacturer	MedChem Express
CASRN	124431-80-7
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Neuroinflammation Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.70
Citations	[1]Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75.\|[2]Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.\|[3]Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.\|[4]Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522(1):21-4.\|[5]Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2-(aryl)alkylthioadenosine derivatives. Acta Pharmacol Sin. 2025 Jan 8.\|Eur J Med Res. 2024 Aug 27;29(1):433.\|J Cell Mol Med. 2025 Mar;29(5):e70458.\|Research Square Print. December 13th, 2022.\|Cell Death Dis. 2020 Mar 23;11(3):202.\|Ecotoxicol Environ Saf. 2022 Dec 12;249:114410.\|Iran J Basic Med Sci. 10, Oct 2021.\|J Neuroinflammation. 2022 Feb 18;19(1):52.\|Neurochem Int. 2021 Feb 9;145:104983.\|Research Square Preprint. 2021 Aug.
Smiles	O=C(O)CCC1=CC=C(CCNC2=NC3=C(N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O4)C(N)=N2)C=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	124431-80-7
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Adenosine Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	535.98
Product Description	CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO: ≥ 20 mg/mL\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	GPCR/G Protein
Clinical information	No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

HY-13201A-10mg-safety-datasheet.pdf