SR1001

Item no.	HY-13421-10mM
Manufacturer	MedChem Express
CASRN	1335106-03-0
Amount	10 mM/1 mL
Quantity options	10 mM/1 mL 10 mg 1 mg 50 mg 5 mg
Category	Neuroscience Neuroinflammation Metabolism Cholesterol & Lipid Metabolism Enzymes Other Fatty Acid Enzymes Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.89
Citations	[1]Solt LA, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 2011 Apr 28;472(7344):491-4.\|[2]Crumbley C, et al. Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα). PLoS One. 2012;7(4):e33804.
Smiles	CC(NC1=NC(C)=C(S(=O)(NC2=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C2)=O)S1)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1335106-03-0
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	REV-ERB; ROR
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	477.40
Product Description	SR1001 is a selective RORα and RORγt inverse agonist with Kis 172 and 111 nM, respectively.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: ≥ 39 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Clinical information	No Development Reported

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HY-13421-10mM-safety-datasheet.pdf