Comparison

Thapsigargin European Partner

Item no. HY-13433-1mg
Manufacturer MedChem Express
CASRN 67526-95-8
Amount 1 mg
Quantity options 10 mg 1 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.95
Citations [1]Geiszt M, et al. Thapsigargin inhibits Ca<sup>2+</sup> entry into human neutrophil granulocytes. Biochem J. 1995 Jan 15;305 ( Pt 2):525-8.|[2]Wang H, et al. Effects of thapsigargin on the proliferation and survival of human rheumatoid arthritis synovialcells. ScientificWorldJournal. 2014 Feb 9;2014:605416.|[3]Garavito-Aguilar ZV, et al. Differential thapsigargin-sensitivities and interaction of Ca2+ stores in human SH-SY5Y neuroblastoma cells. Brain Res. 2004 Jun 18;1011(2):177-86.|[4]Abdullahi A, et al. Modeling Acute ER Stress in Vivo and in Vitro. Shock. 2017 Apr;47(4):506-513.|[5]Mohammed Samer Shaban, et al. Inhibiting coronavirus replication in cultured cells by chemical ER stress. bioRxiv 2020.08.26.266304;|[6]Junsuke Uwada, et al. Store-operated calcium entry (SOCE) contributes to phosphorylation of p38 MAPK and suppression of TNF-α signalling in the intestinal epithelial cells. Cell Signal. 2019 Nov;63:109358.
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ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias 67526-95-8
Shipping Condition Cool pack
Available
Manufacturer - Type
Natural Products
Manufacturer - Applications
Cancer-programmed cell death
Manufacturer - Targets
Apoptosis; Calcium Channel; SARS-CoV
Shipping Temperature
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Molecular Weight
650.75
Product Description
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca2+-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types[1][2][3][4][5].
Manufacturer - Research Area
Cancer; Infection
Solubility
DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway
Anti-infection; Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information
No Development Reported

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 1 mg
Available: In stock
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