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LY-364947

LY-364947

Item no.	HY-13462-10mg
Manufacturer	MedChem Express
CASRN	396129-53-6
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Molecular Targets for Neuroscience Cardiovascular Research Thrombosis & Hemostasis Inhibitors & Compound Libraries Small Molecules By Organ Pancreatic Cancer Neurodegeneration Markers
Type	Inhibitors
Specific against	other
Purity	99.14
Citations	[1]Peng SB, et al. Kinetic characterization of novel pyrazole TGF-beta receptor I kinase inhibitors and their blockade of the epithelial-mesenchymal transition. Biochemistry, 2005, 44(7), 2293-2304.\|[2]Oka M, et al. Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis. Blood, 2008, 111(9), 4571-4579.\|[3]Naka K, et al. TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature, 2010, 463(7281), 676-680.
Smiles	C1(C2=CNN=C2C3=NC=CC=C3)=CC=NC4=CC=CC=C14
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	HTS466284
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	TGF-β Receptor
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	272.30
Product Description	LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGFβR-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGFβR-II[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 15.62 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	TGF-beta/Smad
Clinical information	No Development Reported

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HY-13462-10mg-safety-datasheet.pdf