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Mitoxantrone (dihydrochloride)

Mitoxantrone (dihydrochloride)

Item no.	HY-13502A-100mg
Manufacturer	MedChem Express
CASRN	70476-82-3
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 50 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Breast Cancer Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	98.98
Citations	[1]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.\|[2]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.\|[3]Venza I, et al. Class II-specific histone deacetylase inhibitors MC1568 and MC1575 suppress IL-8 expression in human melanoma cells. Pigment Cell Melanoma Res. 2013 Mar;26(2):193-204.\|[4]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.\|[5]Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93(2):305-308. bioRxiv. 2023 Jan 13.\|BMC Cancer. 2021 Oct 13;21(1):1101.\|Cell Oncol. 2020 Dec;43(6):1099-1116.\|Cell Rep Methods. 2023 Oct 23;3(10):100599.\|Drug Deliv. 2022 Dec;29(1):2561-2578.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|Med Oncol. 2020 Nov 19;37(12):116.\|Nat Commun. 2020 Apr 14;11(1):1792.\|Acta Pharmacol Sin. 2022 Aug 31.\|Acta Pharmacol Sin. 2024 Aug 15.\|Adv Mater. 2024 Apr 21:e2313097.\|bioRxiv. 2024 September 07.\|BMC Cancer. 2025 Jan 7;25(1):24.\|Cancers. 2020 Aug 4;12(8):2169.\|Cell Rep Med. 2024 Feb 20;5(2):101388.\|Drug Metab Dispos. 2025 Feb 3.\|EMBO Mol Med. 2024 Oct 11.\|Exp Cell Res. 2020 Aug 1;393(1):112054.\|Int J Biol Macromol. 2025 Jan 9:139582.\|Int J Biol Sci. 2022 Mar 21;18(6):2568-2582.\|J Am Chem Soc. 2022 Jun 15;144(23):10407-10416.\|J Control Release. 2024 Nov 12:376:1271-1287.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.\|J Pharm Pharmacol. 2022 Jan 5;74(1):41-56.\|J Pharm Pharmacol. 23 November 2021.\|Light Sci Appl. 2024 Oct 31;13(1):304.\|Mol Cell. 2024 Jun 18:S1097-2765(24)00447-7.\|Nat Cell Biol. 2024 May 7.\|Patent. US20240307414A1.\|Pharm Dev Technol. 2021 Apr 30;1-9.\|Pharmacol Res. 2024 May 9:204:107208.\|Research Square Print. November 28th, 2022.\|Talanta. 2024 Mar 23, 125987.\|University of California, Irvine. 2024.
Smiles	O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.[H]Cl.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Mitozantrone (dihydrochloride),NSC 301739 (dihydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; Endogenous Metabolite; Orthopoxvirus; PKC; Topoisomerase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	517.40
Product Description	Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity[1][2][3][4]. Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
Manufacturer - Research Area	Cancer; Infection
Solubility	DMSO : 31.25 mg/mL (ultrasonic)\|H2O : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; TGF-beta/Smad
Clinical information	Launched
Isoform	PKC; Topo II

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