Dxd

Manufacturer	MedChem Express
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Amount	10 mg
Item no.	HY-13631D-10mg
Targets	Topoisomerase; ADC Cytotoxin
CASRN	1599440-33-1
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Dxd (Exatecan derivative for ADC) is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a).
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
MolecularWeight	493.48
Clinical_Information	Phase 2
Manufacturers Research_Area	Cancer
Solubility	DMSO : 40 mg/mL (ultrasonic)
Manufacturers Target	ADC Cytotoxin; Topoisomerase
Isoform	Camptothecins; Topo I
Pathway	Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Manufacturers Product type	ADC Related

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HY-13631D-10mg-safety-datasheet.pdf