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Lomustine

Lomustine

Item no.	HY-13669-500mg
Manufacturer	MedChem Express
CASRN	13010-47-4
Amount	500 mg
Quantity options	10 mM/1 mL 200 mg 500 mg
Category	Oncology Neuroscience Neural Adhesion Molecules Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Testicular & Prostate Cancer
Type	Inhibitors
Specific against	other
Purity	99.90
Citations	[1]Wang P, et al. Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents. Cell Rep. 2015 Dec 22;13(11):2353-2361.\|[2]Harvey KA, et al. Enhanced anticancer properties of lomustine in conjunction with docosahexaenoic acid in glioblastoma cell lines. J Neurosurg. 2015 Mar;122(3):547-56.\|[3]Yagiz K, et al. Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models. Neuro Oncol. 2016 Oct;18(10):1390-401.
Smiles	O=C(NC1CCCCC1)N(CCCl)N=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CCNU,NSC 79037
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; DNA Alkylator/Crosslinker
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	233.70
Product Description	Lomustine (CCNU; NSC 79037) is a DNA alkylating agent, with antitumor activity.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 100 mg/mL\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Autophagy; Cell Cycle/DNA Damage
Clinical information	Launched

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