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Norepinephrine

Norepinephrine

Item no.	HY-13715-500mg
Manufacturer	MedChem Express
CASRN	51-41-2
Amount	500 mg
Quantity options	100 mg 10 mM/1 mL 500 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.43
Formula	C8H11NO3
Citations	ACS Nano. 2022 Aug 23;16(8):12553-12568. Biochem Biophys Res Commun. 2023 Mar 24;657:108-118. bioRxiv. 2023 Oct 13. bioRxiv. 2024 July 31. bioRxiv. 2024 November 03. Cell Commun Signal. 2024 Jul 25;22(1):375. Cell Death Dis. 2020 Aug 18;11(8):644. Cell Mol Immunol. 2023 Jan 5. Cell Rep Med. 2023 May 24;101061. Eur J Pharmacol. 2022 May 12;175022. Food Science and Human Wellness. 2023 Nov;12(6);2061-2072. Gene. 2023 Aug 31;147753. Int J Mol Sci. 2022, 23(20), 12420. J Am Heart Assoc. 2019 Jan 8;8(1):e009871. J Biol Chem. 2024 Oct 23:107924. J Cancer. 2024 Sep 9;15(17):5691-5709. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Aug 15;1092:220-227. J Ethnopharmacol. 2024 Sep 26:118860. J Therm Biol. 2024 Jul 2:123:103906. Nat Commun. 2022 Jul 25;13(1):4278. Nat Commun. 2024 May 7;15(1):3834. Neurochem Int. 2020 Dec 16;104942. Sci Rep. 2022 Jun 15;12(1):9936. SSRN. 2023 May 8. Br J Pharmacol. 2020 Aug;177(15):3389-3402. Cell Rep. 2019 Dec 3;29(10):2936-2943.e4. J Nutr Biochem. 2018 May 1;58:110-118. Leiden University. Institute of Biology Leiden (IBL) , Faculty of Science. Nature. 2024 Dec 18. Neuroscience. 2019 Mar 1;401:59-72. Research Square Preprint. 2021 Aug. Theranostics. 2022 Jun 6;12(10):4718-4733. Cardiovasc Res. 2018 Feb 1;114(2):300-311. Cell Biochem Funct. 2024 Jan 11. FASEB J. 2020 Nov;34(11):14892-14904. [1]MacGregor DA, et al. Relative efficacy and potency of beta-adrenoceptor agonists for generating cAMP in human lymphocytes. Chest. 1996 Jan;109(1):194-200. [2]Littlejohn NK, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep. 2016 Aug 9;16(6):1548-60. [3]Brian P Ramos, et al. Adrenergic pharmacology and cognition: focus on the prefrontal cortex. Pharmacol Ther. 2007 Mar;113(3):523-36. [4]Xinyu Xu, et al. Binding pathway determines norepinephrine selectivity for the human β 1 AR over β 2 AR. Cell Res. 2021 May;31(5):569-579. [5]Xiao D, et al. "Inhibition of DNA methylation reverses norepinephrine-induced cardiac hypertrophy in rats." Cardiovascular research 101.3 (2014): 373-382. [6]Yamazaki, et al. "Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both α1-and β-adrenoceptors." Circulation 95.5 (1997): 1260-1268.
Smiles	OC1=CC=C([C@@H](O)CN)C=C1O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Levarterenol, L-Noradrenaline
Shipping condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Targets	Adrenergic Receptor; Autophagy; Endogenous Metabolite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	169.18
Product Description	Norepinephrine (Levarterenol; L-Noradrenaline) is a potent adrenergic receptor (AR) agonist. Norepinephrine activates α1, α2, β1 receptors[1][2][3][4].
Manufacturer - Research Area	Endocrinology; Cardiovascular Disease; Cancer
Solubility	DMSO : 50 mg/mL (ultrasonic; adjust pH to 2 with HCl)\|H2O : 33.33 mg/mL (ultrasonic; adjust pH to 1 with 1 M HCL)
Manufacturer - Pathway	Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Isoform	Human Endogenous Metabolite; Microbial Metabolite; α adrenergic receptor; β adrenergic receptor
Clinical information	Launched

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HY-13715-500mg-safety-datasheet.pdf