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Quinacrine (dihydrochloride)

Quinacrine (dihydrochloride)

Item no.	HY-13735A-500mg
Manufacturer	MedChem Express
CASRN	69-05-6
Amount	500 mg
Quantity options	100 mg 10 mM x 1 mL 1 g 200 mg 500 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Heart & Blood Cancer
Type	Inhibitors
Specific against	other
Purity	99.38
Citations	[1]Xiaoyang Wu, et al. Quinacrine Inhibits Cell Growth and Induces Apoptosis in Human Gastric Cancer Cell Line SGC-7901. Curr Ther Res Clin Exp. 2012 Feb;73(1-2):52-64.\|[2]Anna Eriksson, et al. Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects. Leuk Res. 2017 Dec;63:41-46.
Smiles	CC(NC1=C(C=C(OC)C=C2)C2=NC3=CC(Cl)=CC=C31)CCCN(CC)CC.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Mepacrine (dihydrochloride),SN-390 (dihydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Autophagy; Mitophagy; Parasite
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	472.88
Product Description	Quinacrine (Mepacrine) dihydrochloride is an orally bioavailable antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine dihydrochloride suppresses NF-κB and activate p53 signaling, which results in the induction of the apoptosis[1].
Manufacturer - Research Area	Cancer; Infection
Solubility	H2O: 13.89 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Apoptosis; Autophagy
Isoform	Plasmodium
Clinical information	Phase 2

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HY-13735A-500mg-safety-datasheet.pdf