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Stattic

Stattic

Item no.	HY-13818-10mM
Manufacturer	MedChem Express
CASRN	19983-44-9
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Neural Transcription Factors Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Gastric Cancer Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.58
Formula	C8H5NO4S
Citations	[1]Lin L, et al. STAT3 as a potential therapeutic target in ALDH+ and CD44+/CD24+ stem cell-like pancreatic cancer cells. Int J Oncol. 2016 Oct 12. [2]John S McMurray, et al. A new small-molecule Stat3 inhibitor. Chem Biol. 2006 Nov;13(11):1123-4. [3]Tsubasa Yokota, et al. STAT3 inhibition attenuates the progressive phenotypes of Alport syndrome mouse model. Nephrol Dial Transplant. 2018 Feb 1;33(2):214-223.
Smiles	O=[N+](C1=CC=C(C=CS2(=O)=O)C2=C1)[O-]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	19983-44-9
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; STAT
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	211.19
Product Description	Stattic is a potent STAT3 inhibitor and inhibits STAT3 phosphorylation (at Y705 and S727)[1]. Stattic inhibits the binding of a high affinity phosphopeptide for the SH2 domain of STAT3[2]. Stattic ameliorates the renal dysfunction in Alport syndrome (AS) mice[3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Isoform	STAT3
Clinical information	No Development Reported

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HY-13818-10mM-safety-datasheet.pdf