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Amiodarone (hydrochloride)

Amiodarone (hydrochloride)

Item no.	HY-14188-500mg
Manufacturer	MedChem Express
CASRN	19774-82-4
Amount	500 mg
Quantity options	10 mM/1 mL 1 g 500 mg 5 g
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]Yihong Zhang,et al. Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking. Biochem Pharmacol. 2016 Aug 1;113:24-35.\|[2]Sabrina Le Bouter, et al. Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart. Circulation. 2004 Nov 9;110(19):3028-35.\|[3]Jie Weng, et al. Amiodarone induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Biomed Pharmacother. 2019 Jul;115:108889.\|[4]Punithavathi D, et al. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br J Pharmacol. 2003 Aug;139(7):1342-50.\|[5]Shayeganpour A, et al. Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models. Biopharm Drug Dispos. 2005 Sep;26(6):249-57. Front Bioeng Biotechnol. 2022 Mar 17;10:826093.\|Viruses. 2021 Jun 28;13(7):1255.\|Biochem Biophys Res Commun. 2020 Feb 19;522(4):862-868.\|Biotechnol Bioeng. 2021 Sep 3.\|Cell. 2022 Dec 8;185(25):4801-4810.e13.\|Cell. 2023 Nov 22;186(24):5363-5374.e16.\|Ecotoxicol Environ Saf. 2021 Apr 1;212:111991.\|Patent. US20180263995A1.\|SSRN. 2023 Nov 8.
Smiles	CCCCC1=C(C(C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)=O)C3=C(O1)C=CC=C3.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	19774-82-4
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Autophagy; Potassium Channel
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	681.77
Product Description	Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM[1]. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts[2]. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias[1].
Manufacturer - Research Area	Cardiovascular Disease; Cancer
Solubility	DMSO: 24.5 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Autophagy; Membrane Transporter/Ion Channel
Clinical information	Launched

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HY-14188-500mg-safety-datasheet.pdf