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Siramesine (hydrochloride)

Siramesine (hydrochloride)

Item no.	HY-14221A-10mM
Manufacturer	MedChem Express
CASRN	224177-60-0
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 2 mg 50 mg 5 mg
Category	Food Safety Hormones Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.69
Citations	Patent. US20220305013A1.\|Adv Sci (Weinh). 2023 Mar 11;e2300311.\|Dean Francis. 2023 Jun.\|J Pharmacol Exp Ther. 2015 Aug;354(2):203-12.
Smiles	FC1=CC=C(N2C=C(CCCCN3CCC4(CC3)OCC5=C4C=CC=C5)C6=C2C=CC=C6)C=C1.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Lu 28-179 (hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Ferroptosis; Sigma Receptor
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	491.04
Product Description	Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 42 mg/mL
Manufacturer - Pathway	Apoptosis; Neuronal Signaling
Isoform	Sigma 1 Receptor
Clinical information	No Development Reported

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HY-14221A-10mM-safety-datasheet.pdf