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Letrozole

Letrozole

Item no.	HY-14248-100mg
Manufacturer	MedChem Express
CASRN	112809-51-5
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 200 mg 500 mg
Category	Oncology Food Safety Hormones Inhibitors & Compound Libraries Small Molecules By Organ Breast Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	99.95
Citations	[1]Bhatnagar AS, et, al. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):1021-7.\|[2]Mitropoulou TN, et, al. Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP-2 and MMP-9) by human epithelial breast cancer cells. Int J Cancer. 2003 Mar 20;104(2):155-60.\|[3]Schieweck K, et, al. Anti-tumor and endocrine effects of non-steroidal aromatase inhibitors on estrogen-dependent rat mammary tumors. J Steroid Biochem Mol Biol. 1993 Mar;44(4-6):633-6.
Smiles	N#CC1=CC=C(C(N2C=NC=N2)C3=CC=C(C#N)C=C3)C=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	CGS 20267
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Autophagy; Cytochrome P450
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	285.30
Product Description	Letrozole (CGS 20267) is a potent, selective, reversible and orally active non-steroidal inhibitor of aromatase, with an IC50 of 11.5 nM. Letrozole selective inhibits estrogen biosynthesis, and can be used for the research of breast cancer[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Autophagy; Metabolic Enzyme/Protease
Isoform	Aromatase/CYP19A1
Clinical information	Launched

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HY-14248-100mg-safety-datasheet.pdf