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Olprinone (Hydrochloride)

Olprinone (Hydrochloride)

Item no.	HY-14254-10mg
Manufacturer	MedChem Express
CASRN	119615-63-3
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.85
Citations	[1]Sugioka M, et al. Identification and characterization of isoenzymes of cyclic nucleotide phosphodiesterase in human kidney and heart, and the effects of new cardiotonic agents on these isoenzymes. Naunyn Schmiedebergs Arch Pharmacol. 1994;350(3):284-293.\|[2]Di Paola R, et al. Olprinone, a PDE3 inhibitor, modulates the inflammation associated with myocardial ischemia-reperfusion injury in rats. Eur J Pharmacol. 2011;650(2-3):612-620.
Smiles	CC(N1)=C(C=C(C#N)C1=O)C2=CN3C(C=C2)=NC=C3.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Loprinone (Hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Phosphodiesterase (PDE)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	286.72
Product Description	Olprinone (Loprinone) Hydrochloride is a potent phosphodiesterase (PDE) 3 inhibitor, with IC50s of 150, 100, 0.35 and 14 μM for PDE1, PDE2, PDE3 and PDE4, respectively. Olprinone Hydrochloride is used for the research of heart failure due to its positive inotropic and vasodilative effects. Anti-inflammatory activity[1][2].
Manufacturer - Research Area	Cardiovascular Disease
Solubility	H2O: ≥ 7.69 mg/mL
Manufacturer - Pathway	Metabolic Enzyme/Protease
Isoform	PDE3
Clinical information	Launched

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HY-14254-10mg-safety-datasheet.pdf