Emodin

Item no.	HY-14393-50mg
Manufacturer	MedChem Express
CASRN	518-82-1
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 200 mg 50 mg
Category	Oncology Food Safety Allergenes Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Breast Cancer Uterine, Ovarian & Cervical Cancer
Type	Inhibitors
Specific against	other
Purity	99.39
Citations	[1]Tin-Yun Ho, et al. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction. Antiviral Res. 2007 May;74(2):92-101.\|[2]Ying Feng, et al. Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice. Br J Pharmacol. 2010 Sep;161(1):113-26.\|[3]Stefania Sarno, et al. Toward the rational design of protein kinase casein kinase-2 inhibitors. Pharmacol Ther. Feb-Mar 2002;93(2-3):159-68.
Smiles	O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Frangula emodin
Shipping Condition	Room temperature
Available
Manufacturer - Type	Natural Products
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	11β-HSD; Autophagy; Casein Kinase; SARS-CoV
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	270.24
Product Description	Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction[1]. Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects[2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice[3].
Manufacturer - Research Area	Cancer
Solubility	Acetone: 10.87 mg/mL (ultrasonic)\|DMSO: 5.41 mg/mL (ultrasonic)\|Ethanol: < 1 mg/mL (ultrasonic)
Manufacturer - Pathway	Anti-infection; Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Stem Cell/Wnt
Isoform	CK2
Clinical information	No Development Reported

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