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Clozapine

Clozapine

Manufacturer	MedChem Express
Category	Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules Neuronal Cell Markers
Type	Inhibitors
Specific against	other
Clone	N/A
Amount	500mg
Item no.	HY-14539-500mg
CASRN	5786-21-0
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Clozapine (HF 1854) is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively[1][2][3]. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM)[4].
StorageTemperature	-20°C, 3 years; 4°C, 2 years (Powder)
Shipping	Room Temperature
Manufacturers Applications	Neuroscience-Neurodegeneration
MolecularWeight	326.82
Clinical_Information	Launched
Manufacturers Research_Area	Neurological Disease
Solubility	DMSO : 50 mg/mL (ultrasonic)
Manufacturers Target	5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; mAChR
Isoform	5-HT2 Receptor; 5-HT6 Receptor; 5-HT7 Receptor; D2 Receptor; mAChR1; mAChR4; α adrenergic receptor
Pathway	GPCR/G Protein; Neuronal Signaling
Manufacturers Product type	Reference compound

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HY-14539-500mg-safety-datasheet.pdf