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Olanzapine

Olanzapine

Item no.	HY-14541-10mM
Manufacturer	MedChem Express
CASRN	132539-06-1
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 250 mg 500 mg 50 mg
Category	Food Safety Histamines Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.96
Citations	[1]APPROVED AGREED-UPON LABELING.\|[2]Olanzapine for Injection, powder, for solution for intramuscular use.\|[3]Vucicevic L, et al. Autophagy inhibition uncovers the neurotoxic action of the antipsychotic drug olanzapine. Autophagy. 2014;10(12):2362-78.\|[4]Karpel-Massler G, et al. Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect. J Neurooncol. 2015 Mar;122(1):21-33.\|[5]Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl). 2006 Jul;186(4):561-71.
Smiles	CC1=CC(C(N2CCN(C)CC2)=N3)=C(S1)NC4=C3C=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY170053
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	5-HT Receptor; Adrenergic Receptor; Apoptosis; Autophagy; Dopamine Receptor; mAChR; Mitophagy
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, protect from light)
Molecular Weight	312.442
Product Description	Olanzapine (LY170053) is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 20 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling
Isoform	5-HT2 Receptor; 5-HT6 Receptor; Dopamine Receptor; lactoferrin; mLAG-3; MUC2; α-1 microglobulin
Clinical information	Launched

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HY-14541-10mM-safety-datasheet.pdf