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Donepezil

Donepezil

Item no.	HY-14566-10mg
Manufacturer	MedChem Express
CASRN	120014-06-4
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Brain Cancer Nervous System Cancer
Type	Inhibitors
Specific against	other
Purity	99.91
Citations	[1]Ogura, H., et al., Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol, 2000. 22(8): p. 609-13.\|[2]Snape, M.F., et al., A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology, 1999. 38(1): p. 181-93.\|[3]Huang, Z.H., et al., Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury. CNS Neurosci Ther, 2012. 18(2): p. 185-7. bioRxiv. 2024 Dec 23:2024.12.22.629999.\|Chem Biodivers. 2025 Jan 7:e202402771.\|Comput Struct Biotec. 2023 Feb 24.\|Eur J Med Chem. 2023 Dec 21, 116071.\|Foods. 2022, 11(14), 2095.\|J Ethnopharmacol. 2024 Nov 9;338(Pt 1):119017.\|J Ethnopharmacol. 2025 Mar 10:119619.\|Journal of Pharmaceutical Investigation. 2021 Mar 31.\|Phytomedicine. 2024 Jun 4:131:155802.\|Alzheimers Res Ther. 2025 Feb 14;17(1):43.\|Clin Transl Med. 2021 May 28.\|J Integr Neurosci. 2023 May 16, 22(3), 76.\|Patent. US20210378961A1.\|Research Square Preprint. 2024 Apr 23.
Smiles	O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	E2020 (free base)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neuromodulation
Manufacturer - Targets	Cholinesterase (ChE)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	379.49
Product Description	Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
Manufacturer - Research Area	Neurological Disease; Cancer
Solubility	DMSO: 33.33 mg/mL (ultrasonic)
Manufacturer - Pathway	Neuronal Signaling
Isoform	AChE
Clinical information	Launched

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HY-14566-10mg-safety-datasheet.pdf