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(-)-DHMEQ

(-)-DHMEQ

Item no.	HY-14645-10mg
Manufacturer	MedChem Express
CASRN	287194-40-5
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 25 mg 2 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Bladder Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.47
Citations	[1]Quach HT, et al. Eudesmane-Type Sesquiterpene Lactones Inhibit Nuclear Translocation of the Nuclear Factor κB Subunit RelB in Response to a Lymphotoxin β Stimulation. Biol Pharm Bull. 2017;40(10):1669-1677.\|[2]Yinzhi Lin, et al. Inhibition of Late and Early Phases of Cancer Metastasis by the NF-κB Inhibitor DHMEQ Derived from Microbial Bioactive Metabolite Epoxyquinomicin: A Review.\|[3]Mariko Watanabe, et al. Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia. Blood. 2005 Oct 1;106(7):2462-71.
Smiles	O=C1[C@@H](O2)[C@@H]2[C@@H](O)C(NC(C3=C(O)C=CC=C3)=O)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Dehydroxymethylepoxyquinomicin
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	NF-κB
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, stored under nitrogen)
Molecular Weight	261.23
Product Description	(-)-DHMEQ (Dehydroxymethylepoxyquinomicin) is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity[1][2][3].
Manufacturer - Research Area	Cancer; Inflammation/Immunology
Solubility	DMSO: 95 mg/mL (ultrasonic)
Manufacturer - Pathway	NF-κB
Isoform	RelA/p65; RelB
Clinical information	No Development Reported

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HY-14645-10mg-safety-datasheet.pdf