AZ3146

Item no.	HY-14710-10mg
Manufacturer	MedChem Express
CASRN	1124329-14-1
Amount	10 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.42
Citations	[1]Hewitt L, et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol. 2010 Jul 12;190(1):25-34.\|[2]Liu X, et al. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015 Oct 27;6(33):34309-20.\|[3]Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75(16):3340-54.
Smiles	CN(CC1)CCC1OC2=CC=C(NC3=NC(N(C4CCCC4)C(N5C)=O)=C5C=N3)C(OC)=C2
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1124329-14-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Mps1
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	452.55
Product Description	AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Cytoskeleton
Clinical information	No Development Reported

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HY-14710-10mg-safety-datasheet.pdf