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Imeglimin (hydrochloride)

Imeglimin (hydrochloride)

Item no.	HY-14771A-50mg
Manufacturer	MedChem Express
CASRN	775351-61-6
Amount	50 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Metabolism Diabetes Cholesterol & Lipid Metabolism Regulation of Appetite Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Vial G, et al. Imeglimin normalizes glucose tolerance and insulin sensitivity and improves mitochondrialfunction in liver of a high-fat, high-sucrose diet mice model. Diabetes. 2015 Jun;64(6):2254-64.\|[2]Detaille D, et al. Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration. Cell Death Discov. 2016 Jan 18;2:15072.
Smiles	[H]Cl.NC1=N[C@@H](C)N=C(N(C)C)N1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	EMD 387008 hydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Metabolism-sugar/lipid metabolism
Manufacturer - Targets	Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	191.66186
Product Description	Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. Imeglimin also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA and improves mitochondrial function[1].
Manufacturer - Research Area	Metabolic Disease
Solubility	DMSO: 25 mg/mL (ultrasonic)\|H2O: ≥ 50 mg/mL
Manufacturer - Pathway	Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Clinical information	Launched

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HY-14771A-50mg-safety-datasheet.pdf