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Inolitazone (dihydrochloride)

Inolitazone (dihydrochloride)

Item no.	HY-14792B-10mM
Manufacturer	MedChem Express
CASRN	223132-38-5
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	98.86
Citations	[1]Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17.\|[2]Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44. Cancer Med. 2018 May;7(5):1955-1966. \|Int J Oncol. 2018 Jun;52(6):1991-2000. \|Exp Cell Res. 2017 Dec 15;361(2):246-256. \|Front Microbiol. 2019 Jan 8;9:3257.
Smiles	O=C(N1)SC(CC2=CC=C(OCC3=NC4=CC=C(OC5=CC(C)=C(N)C(C)=C5)C=C4N3C)C=C2)C1=O.Cl.Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Efatutazone (dihydrochloride),CS-7017 (dihydrochloride),RS5444 (dihydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	PPAR
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	575.51
Product Description	Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a novel high-affinity PPARγ agonist that is dependent upon PPARγ for its biological activity with IC50 of 0.8 nM for growth inhibition.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 2 mg/mL (ultrasonic; warming; heat to 80°C)\|H2O: < 0.1 mg/mL
Manufacturer - Pathway	Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Isoform	PPARγ
Clinical information	Phase 2

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HY-14792B-10mM-safety-datasheet.pdf