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Givinostat (hydrochloride)

Givinostat (hydrochloride)

Item no.	HY-14842A-100mg
Manufacturer	MedChem Express
CASRN	199657-29-9
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1 ea 50 mg 5 mg
Category	Oncology Neuroscience Targets for Rodent Neurosciences Aging & Neurological Disorders Inhibitors & Compound Libraries Small Molecules By Organ Bladder Cancer Colorectal Cancer
Type	Inhibitors
Specific against	other
Purity	98.06
Citations	[1]Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78.\|[2]Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39.\|[3]Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15. Cell Death Dis. 2020 Sep 15;11(9):753.\|Acta Pharmacol Sin. 2021 Apr 13.\|bioRxiv. 2025 January 15.\|Cell Prolif. 2021 May 24;e13072.\|Commun Biol. 2021 Oct 29;4(1):1235.\|J Am Chem Soc. 2024 Sep 27.\|J Orthop Transl. 29 (2021) 106-112.\|Neuroscience. 2021 Apr 13;S0306-4522(21)00185-8.\|Patent. US20240252638A1.\|SSRN. 2024 Mar 13.\|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.
Smiles	O=C(OCC1=CC=C2C=C(CN(CC)CC)C=CC2=C1)NC3=CC=C(C(NO)=O)C=C3.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	ITF-2357 hydrochloride
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	HDAC
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	457.95
Product Description	Givinostat (ITF-2357) hydrochloride is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively[1][2][3].
Manufacturer - Research Area	Cancer
Solubility	DMSO: 175 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage; Epigenetics
Isoform	HD1; HD2; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC6; HDAC7; HDAC8; HDAC9
Clinical information	Launched

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Amount: 100 mg

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