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Diclofenac

Diclofenac

Item no.	HY-15036-5g
Manufacturer	MedChem Express
CASRN	15307-86-5
Amount	5 g
Quantity options	10 g 10 mM/1 mL 500 mg 5 g
Category	Neuroscience Aging & Neurological Disorders Cardiovascular Research Thrombosis & Hemostasis Atherosclerosis Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.98
Citations	[1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.\|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.\|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. Anal Chem. 2025 Jun 3;97(21):11099-11109. Biomater Res. 2025 Nov 7:29:0280. Biomater Res. 2025 Oct 22. bioRxiv. 2024 Apr 7. Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. Cell Rep. 2025 Feb 7;44(2):115263. Chem Biol Interact. 2021 Apr 1:338:109425. Chemosphere. 2019 Jun:225:378-387. Ecotoxicol Environ Saf. 2025 Nov 15:307:119433. Eur J Drug Metab Pharmacokinet. 2022 Sep;47(5):639-652. Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov. Int J Mol Sci. 2022 Oct 11;23(20):12066. J Hazard Mater. 2015 May 30;289:18-27. J Pharm Biomed Anal. 2021 Jul 15:201:114105. J Phys Chem Solids. 2017 October;109:117-123. ACS Infect Dis. 2024 Aug 9;10(8):2860-2869. Arch Microbiol. 2024 Jun 7;206(7):289. Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. Cell Rep Methods. 2023 Oct 23;3(10):100599. Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. Toxicol Mech Methods. 2019 Nov;29(9):654-664. Biotechnol Bioeng. 2021 Dec;118(12):4687-4698. Pharm Res. 2022 Oct;39(10):2515-2527.
Smiles	O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	15307-86-5
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Apoptosis; COX
Manufacturer - HS Code	H301, H361, H372, H411
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	296.15
Product Description	Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
Manufacturer - Research Area	Inflammation/Immunology; Cancer
Solubility	DMSO : 125 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; Immunology/Inflammation
Clinical information	Launched
Isoform	COX-1; COX-2
UNSPSC Code	12352005
Precautionary	H301, H361, H372, H411

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