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Dizocilpine (maleate)

Dizocilpine (maleate)

Item no.	HY-15084-10mM
Manufacturer	MedChem Express
CASRN	77086-22-7
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Food Safety Allergenes Neuroscience Molecular Targets for Neuroscience Targets for Rodent Neurosciences Neural Signaling Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.99
Citations	[1]Wong EH, et al. The anticonvulsant MK-801 is a potent N-Me-D-Asp antagonist. Proc Natl Acad Sci U S A. 1986 Sep;83(18):7104-8.\|[2]Wegener N, et al. Evaluation of brain pharmacokinetics of (+)MK-801 in relation to behaviour. Neurosci Lett. 2011 Sep 26;503(1):68-72. \|[3]Huettner JE, et al. Block of N-Me-D-Asp-activated current by the anticonvulsant MK-801: selective binding to open channels. Proc Natl Acad Sci U S A. 1988 Feb;85(4):1307-11.\|[4]Thomas DM, et al. MK-801 and dextromethorphan block microglial activation and protect against neurotoxicity. Brain Res. 2005 Jul 19;1050(1-2):190-8.\|[5]Brown TE, et al. The NMDA antagonist MK-801 disrupts reconsolidation of a cocaine-associated memory for conditioned place preference but not for self-administration in rats. Learn Mem. 2008 Dec 2;15(12):857-65.\|[6]Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-Me-D-Asp receptor activation. Neuroreport. 2017 May 24;28(8):444-450.\|[7]Iijima Y, et al. Modification by MK-801 (dizocilpine), a noncompetitive NMDA receptor antagonist sensitization: evaluation by ambulation in mice. Nihon Shinkei Seishin Yakurigaku Zasshi. 1996 Feb;16(1):11-8. Cell. 2023 Nov 22;186(24):5347-5362.e24. Eur J Neurosci. 2024 Sep;60(5):4830-4842. Eur J Pharmacol. 2019 Aug 15:857:172427. Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641. Front Cell Dev Biol. 2020 Feb 4;8:24. Front Cell Neurosci. 2019 Jun 25:13:276. Front Neurosci. 2019 Nov 19;13:1225. Life Sci. 2022 Apr 15:295:120419. Mol Psychiatry. 2022 Sep;27(9):3885-3897. Neuropharmacology. 2024 Dec 24:110284. Neuroreport. 2017 May 24;28(8):444-450. Prog Neuropsychopharmacol Biol Psychiatry. 2025 Dec 20:143:111555. Psychoneuroendocrinology. 2024 Oct:168:107138. Psychopharmacology (Berl). 2025 Mar;242(3):651-661. Res Sq. 2024 Jul 15. Sci Bull. 2025 Apr 15;70(7):1126-1138. SSRN. 2025 Jun 18. Basic Clin Neurosci. 2023 Jan-Feb;14(1):103-116. Behav Brain Res. 2026 Feb 26:498:115917. Bioorg Med Chem. 2022 Apr 1:59:116675. Br J Pharmacol. 2020 Oct;177(20):4720-4733. Brain Res. 2023 Aug 1:1812:148409. Cell Biosci. 2023 Mar 16;13(1):57. Eur J Pharmacol. 2022 Dec 5:936:175343. Front Biosci (Landmark Ed). 2023 Jul 19;28(7):140. Int J Mol Sci. 2022 Dec 18;23(24):16150. J Cell Mol Med. 2020 Aug;24(16):9287-9299. J Med Chem. 2023 May 11;66(9):6274-6287. J Orthop Surg Res. 2025 Jan 23;20(1):83. J Physiol. 2023 Aug;601(16):3585-3604. Mol Neurobiol. 2024 Jul;61(7):4166-4177. Molecules. 2023 Mar 2;28(5):2304. Nat Neurosci. 2022 Jan;25(1):39-49. Neuropharmacology. 2025 Jan 20:110318. Neurosci Lett. 2023 Sep 25:814:137471. RSC Adv. 2022 Oct 3;12(43):28098-28103. Sci Rep. 2025 May 25;15(1):18255. Virulence. 2025 Dec;16(1):2490208.
Smiles	C[C@]12C3=CC=CC=C3C[C@@H](N2)C4=CC=CC=C14.O=C(O)/C=C\C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	(+)-MK 801 Maleate
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Neuroscience-Neurodegeneration
Manufacturer - Category	Reference compound / Active compounds
Manufacturer - Targets	iGluR
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	337.37
Product Description	Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive NMDA receptor antagonist with Kd of 37.2 nM in rat brain membranes.
Manufacturer - Research Area	Neurological Disease
Solubility	DMSO : 133.33 mg/mL (ultrasonic)\|Ethanol : 25 mg/mL (ultrasonic)\|H2O : 7.69 mg/mL (ultrasonic)
Manufacturer - Pathway	Membrane Transporter/Ion Channel; Neuronal Signaling
Clinical information	No Development Reported
Isoform	NMDA Receptor
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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