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Apoptozole

Apoptozole

Item no.	HY-15098-10mg
Manufacturer	MedChem Express
CASRN	1054543-47-3
Amount	10 mg
Quantity options	10 mM/1 mL 10 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Neuroinflammation Protein Aggregation, Clearance & Misfolding Inhibitors & Compound Libraries Small Molecules Cytoskeleton Markers
Type	Inhibitors
Specific against	other
Purity	99.42
Citations	[1]Williams DR, et al. An apoptosis-inducing small molecule that binds to heat shock protein 70. Angew Chem Int Ed Engl. 2008;47(39):7466-9.\|[2]Cho HJ, et al. Probing the effect of an inhibitor of an ATPase domain of Hsc70 on clathrin-mediated endocytosis. Mol Biosyst. 2015 Oct;11(10):2763-9.\|[3]Ko SK, et al. A small molecule inhibitor of ATPase activity of HSP70 induces apoptosis and has antitumor activities. Chem Biol. 2015 Mar 19;22(3):391-403.
Smiles	NC(C(C=C1)=CC=C1CN2C(C3=CC=C(OC)C=C3)=C(C4=CC=C(OC)C=C4)N=C2C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Apoptosis Activator VII
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; HSP
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	625.56
Product Description	Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, with Kds of 0.21 and 0.14 μM, respectively, and can induce apoptosis.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 100 mg/mL
Manufacturer - Pathway	Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Isoform	HSP70
Clinical information	No Development Reported

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HY-15098-10mg-safety-datasheet.pdf