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Monomethyl auristatin E

Monomethyl auristatin E

Manufacturer	MedChem Express
Category	Oncology Metabolism Diabetes Inhibitors & Compound Libraries Small Molecules By Organ Pancreatic Cancer
Type	Inhibitors
Specific against	other
Amount	10 mg
Item no.	HY-15162-10mg
Targets	Microtubule/Tubulin; ADC Cytotoxin; Apoptosis
CASRN	474645-27-7
eClass 6.1	30220300
eClass 9.0	32160605
Available
Product Description	Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.
StorageTemperature	-20°C (Powder, sealed storage, away from moisture and light)
Shipping	Blue Ice
MolecularWeight	717.98
Clinical_Information	Phase 4
Manufacturers Research_Area	Cancer
Solubility	DMSO : ≥ 48 mg/mL\|Ethanol : 50 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturers Target	ADC Cytotoxin; Apoptosis; Microtubule/Tubulin
Isoform	Auristatin
Pathway	Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Manufacturers Product type	ADC Related

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HY-15162-10mg-safety-datasheet.pdf