Comparison

Icotinib (Hydrochloride) European Partner

Item no. HY-15164-50mg
Manufacturer MedChem Express
CASRN 1204313-51-8
Amount 50 mg
Quantity options 100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category
Type Inhibitors
Specific against other
Purity 99.89
Citations [1]Tan F, et al. Icotinib (BPI-2009H), a novel EGFR tyrosine kinase inhibitor, displays potent efficacy in preclinical studies. Lung Cancer. 2012 May;76(2):177-82.
Biochem Pharmacol. 2016 Dec 1;121:67-77. |Mol Syst Biol. 2023 Dec 18.|Science. 2017 Dec 1;358(6367):eaan4368.|Breast Cancer Res Treat. 2025 Mar 7.|Cell Rep Med. 2023 Jan 10;100911.|Clin Chim Acta. 2022 Jan 6;S0009-8981(21)00457-5.|Eur J Pharmacol. 2019 May 5;850:141-149.|J Pharmaceut Biomed. 2023 Jan 26.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.
Smiles C#CC1=CC(NC2=C(C=C(OCCOCCOCCO3)C3=C4)C4=NC=N2)=CC=C1.[H]Cl
ECLASS 10.1 32160490
ECLASS 11.0 32160490
UNSPSC 12000000
Alias BPI-2009H
Shipping Condition Room temperature
Available
Manufacturer - Type
Reference compound
Manufacturer - Applications
Cancer-Kinase/protease
Manufacturer - Targets
EGFR
Shipping Temperature
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Molecular Weight
427.88
Product Description
Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC50 of 5 nM; also inhibits mutant EGFRL858R, EGFRL858R/T790M, EGFRT790M and EGFRL861Q. Icotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Manufacturer - Research Area
Cancer
Solubility
DMSO: 25 mg/mL (ultrasonic)|H2O: < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Isoform
EGFR/ErbB1/HER1
Clinical information
Launched

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50 mg
Available: In stock
available

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?
 
Close