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Buparlisib (Hydrochloride)

Buparlisib (Hydrochloride)

Item no.	HY-15180-10mM
Manufacturer	MedChem Express
CASRN	1312445-63-8
Amount	10mM/1mL
Quantity options	100 mg 10mM/1mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Molecular Targets for Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Gastric Cancer Lymphatic System Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.88
Formula	C18H22ClF3N6O2
Citations	Cell Rep. 2020 Sep 29;32(13):108196. ACS Appl Mater Interfaces. 2019 Apr 3;11(13):12342-12356. Am J Transl Res. 2019 Sep 15;11(9):6055-6065. Anticancer Res. 2018 Jun;38(6):3375-3385. Autophagy. 2022 Jul;18(7):1551-1571. Biomed Pharmacother. 2024 Oct 16:180:117569. Biomedicines. 2022, 10(8), 1988. bioRxiv. 2022 Aug 02. bioRxiv. 2023 Aug 13. bioRxiv. 2023 Jul 24. bioRxiv. 2024 Dec 10:2024.12.09.627542. bioRxiv. 2025 February 23. BMC Anesthesiol. 2021 Aug 30;21(1):210. Brain Behav. 2018 Nov;8(11):e01123. Cancer Cell Int. 2020 Mar 18;20:86. Cancer Commun (Lond). 2022 Feb 18. Cancer Discov. 2018 Mar;8(3):354-369. Cancer Discov. 2019 Sep;9(9):1306-1323. Cancer Discov. 2020 Aug;10(8):1226-1239. Cancer Immunol Immunother. 2024 May 7;73(7):122. Cancer Lett. 2019 Jan;440-441:54-63. Cancer Res. 2022 Jul 27;CAN-22-0042. Cancers (Basel). 2022, 14(22), 5481 Cancers (Basel). 2024 Aug 7;16(16):2785. Cell Commun Signal. 2019 May 15;17(1):44. Cell Rep. 2024 Apr 23;43(5):114132. Cell Syst. 2020 Jan 22;10(1):66-81.e11. Clin Med Insights Oncol. 2024 Oct 16:18:11795549241285387. Cold Spring Harb Mol Case Stud. 2020 Jun 12;6(3):a004853. Diabetologia. 2021 Feb 11. Endocrinology. 2023 Sep 13;bqad135. Eur J Pharmacol. 2023 May 2;175747. Gastroenterologie, Hepatologie und Endokrinologie. 2020 Oct. Harvard Medical School LINCS LIBRARY Hepatol Commun. 2019 Feb 5;3(3):423-436. In Vitro Cell Dev Biol Anim. 2021 May 5. J Cell Biol. 2020 Dec 7;219(12):e202001031. J Cell Biol. 2023 Sep 4;222(9):e202208150. J Clin Endocrinol Metab. 2021 Jan 1;106(1):e232-e246. J Exp Med. 2023 Nov 6;220(11):e20211743. J Transl Med. 2024 Nov 7;22(1):1004. JCI Insight. 2024 Dec 20;9(24):e178535. Journal of the Endocrine Society. 2021 Jun 1. Mol Carcinog. 2022 Apr 13. Mol Carcinog. 2024 Apr 17 Molecules. 2020 Apr 23;25(8):1980. Nat Biomed Eng. 2018 Aug;2(8):578-588. Nat Cancer. 2024 Jul 11. Nat Commun. 2020 May 19;11(1):2487. Nat Commun. 2021 Jun 8;12(1):3444. Nat Commun. 2022 Sep 29;13(1):5723. Nat Med. 2016 Jul;22(7):723-6. Nature. 2018 Aug;560(7719):499-503. Nature. 2022 Dec;612(7940):555-563. Nature. 2024 Sep;633(8031):895-904. Oncogene. 2016 Jul 7;35(27):3607-12. Oncogene. 2022 Jan 20. Oncoimmunology. 2019 Mar 16;8(5):e1581556. Patent. US20160215053A1. Patent. US20210236501A1. PLoS One. 2016 Jan 28;11(1):e0147682. PLoS One. 2018 Jul 5;13(7):e0200014. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9570-E9579. Programa de Doctorado en Biomedicina. 2020 Sep. Prostate. 2018 Feb;78(3):166-177. Research Square Print. 10 Jan 2023. Research Square Print. November 7th, 2022 Sci Adv. 2022 Jan 21;8(3):eabh2635. Sci Rep. 2019 Jan 30;9(1):978. Sci Signal. 2019 May 28;12(583). pii: eaaw9450. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Sci Transl Med. 2023 Feb 22;15(684):eade1857. Science. 2025 Mar 14;387(6739):eadm9805. University of Gothenburg. 2023 Jun 27. World J Gastroenterol. 2023 Oct 28. [1]Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9. [2]Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity with dexamethasone. J Mol Med (Berl). 2012 Jun;90(6):695-706.
Smiles	NC(N=C1)=CC(C(F)(F)F)=C1C2=NC(N3CCOCC3)=NC(N4CCOCC4)=C2.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	BKM120 (Hydrochloride); NVP-BKM120 (Hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; PI3K
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	446.85
Product Description	Buparlisib Hydrochloride (BKM120 Hydrochloride) is a pan-class I PI3K inhibitor, with IC50 of 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO : ≥ 50 mg/mL
Manufacturer - Pathway	Apoptosis; PI3K/Akt/mTOR
Isoform	PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; Vps34
Clinical information	Phase 3

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HY-15180-10mM-safety-datasheet.pdf