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Nirogacestat

Nirogacestat

Item no.	HY-15185-10mM
Manufacturer	MedChem Express
CASRN	1290543-63-3
Amount	10 mM/1 mL
Quantity options	100 mg 10 mM/1 mL 10 mg 1 mg 25 mg 50 mg 5 mg
Category	Food Safety Drugs Neuroscience Molecular Targets for Neuroscience Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.83
Citations	[1]Wei P, et al. Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design. Mol Cancer Ther. 2010 Jun;9(6):1618-28. ACS Appl Mater Interfaces. 2024 Sep 11;16(36):47075-47088. Cancer Cell. 2021 Mar 8;39(3):380-393.e8. EBioMedicine. 2025 Aug 15:119:105879. EMBO Mol Med. 2017 Jul;9(7):950-966. Int J Oncol. 2018 Jul;53(1):99-112. J Biol Chem. 2019 Jul 19;294(29):11276-11285. J Biol Chem. 2021 Jan-Jun:296:100593. J Clin Invest. 2020 Feb 3;130(2):612-624. Mol Immunol. 2018 Jul:99:191-198. Nat Biotechnol. 2024 Nov 25. Nat Mater. 2025 Feb 17. Nat Med. 2023 Sep;29(9):2295-2306. Neuron. 2023 Jun 21;111(12):1898-1913.e5. Research Square Print. 2023 Mar 20. bioRxiv. 2025 May 28.
Smiles	FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	PF-3084014
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Category	Reference compound / Active compounds; API
Manufacturer - Targets	Apoptosis; γ-secretase
Manufacturer - HS Code	H302, H315, H319, H335
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	489.64
Product Description	Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1].
Manufacturer - Research Area	Cancer
Solubility	DMSO : 28.57 mg/mL (ultrasonic)\|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Manufacturer - Pathway	Apoptosis; Neuronal Signaling; Stem Cell/Wnt
Clinical information	Launched
UNSPSC Code	12352005
Precautionary	H302, H315, H319, H335

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