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AZ505 (ditrifluoroacetate)

AZ505 (ditrifluoroacetate)

Item no.	HY-15226A-25mg
Manufacturer	MedChem Express
CASRN	1035227-44-1
Amount	25 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Bladder Cancer Breast Cancer
Type	Inhibitors
Specific against	other
Purity	99.91
Citations	[1]Komatsu S, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015 Jan 20;112(2):357-64.\|[2]Ferguson AD, et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73. Development. 2020 Sep 28;147(18):dev190678. \|Exp Cell Res. 2021 May 17;112649.\|Mol Carcinog. 2023 Apr 10.\|Am J Physiol Renal Physiol. 2022 Jun 27.\|Biomedicines. 2024 Oct 8;12(10):2279.\|Cell Death Dis. 2018 Feb 27;9(3):326.\|Cell Death Dis. 2021 May 2;12(5):439.\|Cell Death Dis. 2022 Jan 12;13(1):52.\|Cell Death Discov. 2022 Jun 6;8(1):274.\|Cells. 2022 Apr 8;11(8):1262.\|Chem Rev. 2021;28(4):297-305.\|FASEB J. 2021 Jul;35(7):e21715.\|J Clin Invest. 2017 Jun 30;127(7):2751-2764.\|Mol Carcinog. 2023 May 5.\|Oncogene. 2021 Apr;40(15):2711-2724.\|Research Square Preprint. 2021 Oct.\|Research Square Print. 2023 Mar 21.\|Sci Adv. 2020 Oct 30;6(44):eabb3154.\|Sci Adv. 2023 Jun 16;9(24):eade6624.\|Theranostics. 2019 Oct 22;9(26):8377-8391.
Smiles	O=C(N(C1CCCCC1)CCNCCC2=C(OCC(N3)=O)C3=C(O)C=C2)CCNCCC4=CC=C(Cl)C(Cl)=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	1035227-44-1
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Histone Methyltransferase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	805.59
Product Description	AZ505 ditrifluoroacetate is a potent and selective SMYD2 inhibitor with IC50 of 0.12 μM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: ≥ 125 mg/mL
Manufacturer - Pathway	Epigenetics
Isoform	SMYD2
Clinical information	No Development Reported

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HY-15226A-25mg-safety-datasheet.pdf