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Tenofovir alafenamide fumarate

Tenofovir alafenamide fumarate

Item no.	HY-15232A-100mg
Manufacturer	MedChem Express
CASRN	379270-38-9
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Specific against	other
Purity	99.87
Citations	[1]Babusis D, et al. Mechanism for effective lymphoid cell and tissue loading following oral administration of nucleotide prodrug GS-7340. Mol Pharm. 2013 Feb 4;10(2):459-66.\|[2]Ruane PJ, et al. Antiviral activity, safety, and pharmacokinetics/pharmacodynamics of tenofovir alafenamide as 10-day monotherapy in HIV-1-positive adults. J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):449-55. Univerzita Karlova v Praz. 2021 Jun.\|Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02143-18.\|Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02143-18.\|J Antimicrob Chemother. 2017 Jun 1;72(6):1731-1740.\|J Gastroenterol. 2020 Apr;55(4):441-452\|J Med Chem. 2024 May 1.\|Pharmaceutics. 2021, 13(10), 1656.\|Research Square Print. 2023 Mar 20.
Smiles	NC1=NC=NC2=C1N=CN2C[C@@H](C)OC[P@](OC3=CC=CC=C3)(N[C@@H](C)C(OC(C)C)=O)=O.O=C(O)/C=C/C(O)=O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GS-7340 (fumarate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-anti-virus
Manufacturer - Targets	HIV; Reverse Transcriptase
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	592.54
Product Description	Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral proagent of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
Manufacturer - Research Area	Infection; Cancer
Solubility	DMSO: ≥ 36 mg/mL\|H2O: ≥ 25 mg/mL
Manufacturer - Pathway	Anti-infection
Isoform	HIV-1; HIV-2
Clinical information	Launched

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HY-15232A-100mg-safety-datasheet.pdf