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Baricitinib

Baricitinib

Item no.	HY-15315-5mg
Manufacturer	MedChem Express
CASRN	1187594-09-7
Amount	5 mg
Quantity options	100 mg 10mM/1mL 10 mg 200 mg 500 mg 50 mg 5 mg
Category	Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes Glucose Homeostasis Neural Transcription Factors Inhibitors & Compound Libraries Small Molecules
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.97
Formula	C16H17N7O2S
Citations	ACS Nano. 2024 Mar 4. Acta Pharmacol Sin. 2020 Aug 27. Adv Sci (Weinh). 2020 Sep 24;7(21):2002518. Adv Sci (Weinh). 2024 Dec 5:e2410360. bioRxiv. 2018 Feb. bioRxiv. 2020 Jun. bioRxiv. 2020 Mar. bioRxiv. 2024 Jul 12:2024.07.11.603146. bioRxiv. 2024 July 07. bioRxiv. 2025 February 21. Br J Pharmacol. 2024 Sep 2. Cancer Res. 2021 Dec 15;81(24):6131-6141. Cell. 2021 Apr 15;184(8):2167-2182.e22. Chemrxiv. 2023 Aug 3. Chemrxiv. Aug 11, 2021. Diabetologia. 2023 Nov 4. Drug Resist Updat. 2025 Feb 28. Eur J Pharm Sci. 2024 Jul 4:106845. Heliyon. 2018 Nov 26;4(11):e00979. Inflammation. 2021 Feb;44(1):206-216. Institute of Natural Medicine,University of Toyama, Japan. 2018, Nov. Int Immunopharmacol. 2022 Jul 15;110:109044. Int Immunopharmacol. 2024 Aug 9:140:112894. Int J Obes (Lond). 2015 Nov;39(11):1607-18. J Allergy Clin Immunol. 2023 Dec 8:S0091-6749(23)02411-9. J Autoimmun. 2022 Feb;127:102793. J Clin Invest. 2021 Dec 15;131(24):e145501. J Dermatol Sci. 2024 Oct 22. J Exp Med. 2024 Mar 4;221(3):e20230683. J Immunol. 2013 Oct 1;191(7):3568-77. Karolinska Institutet. 2024 May 31. Mol Syst Biol. 2023 Dec 18. Nat Commun. 2023 Apr 24;14(1):2342. Pharmacol Rep. 2024 Aug 19. Platelets. 2021 Jun 7;1-12. PLoS One. 2017 Jul 14;12(7):e0181126. Res Sq. 2024 Jul 16. Research Square Preprint. 2024 Mar 21. Rheumatology. 2023 Jan 17;kead013. RSC Adv. 2018, 8, 21534-21540. Sci Adv. 2024 Mar 22;10(12):eadl0368. Sci Immunol. 2024 Jul 12;9(97):eadn0178. Sci Rep. 2022 May 12;12(1):7843. Sci Transl Med. 2018 Jul 18;10(450):eaaq1093. Science. 2017 Dec 1;358(6367):eaan4368. Signal Transduct Target Ther. 2021 Apr 24;6(1):165. Toxicol Sci. 2020 Aug 1;176(2):410-422. bioRxiv. 2020 Oct 5;2020.10.04.325415. Commun Biol. 2021 Jun 2;4(1):654. J Clin Invest. 2024 Oct 1;134(19):e176828. Research Square Preprint. 2020 Dec. [1]Fridman JS, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010 May 1;184(9):5298-307. [2]Jabbari A, et al. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib. EBioMedicine. 2015 Feb 26;2(4):351-5. [3]Khan IM, et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration resistance. Int J Obes (Lond). 2015 Nov;39(11):1607-18.
Smiles	N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(CC)=O)C1
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LY3009104; INCB028050
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	JAK
Shipping Temperature	Room Temperature
Storage Conditions	-20°C, 3 years; 4°C, 2 years (Powder)
Molecular Weight	371.42
Product Description	Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO : 25 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Isoform	JAK1; JAK2; JAK3; Tyk2
Clinical information	Launched

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HY-15315-5mg-safety-datasheet.pdf