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Tetrahydrouridine (dihydrate)

Tetrahydrouridine (dihydrate)

Item no.	HY-15345-5mg
Manufacturer	MedChem Express
Amount	5 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 1420 ug (100 mM x 50 ul in Water) 1 mg 25 mg 50 mg 568 ug (100 mM x 20 ul in Water) 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer
Type	Inhibitors
Specific against	other
Purity	99.86
Citations	[1]Funamizu N, et al. Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels. PLoS One. 2012;7(5):e37424.\|[2]Terse P, et al. Subchronic oral toxicity study of decitabine in combination with tetrahydrouridine in CD-1 mice. Int J Toxicol. 2014 Mar-Apr;33(2):75-85. Biochem Biophys Res Commun. 2023 JUn 16.\|Int J Nanomedicine. 2024 Dec 11:19:13391-13410.
Smiles	O=C1N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)CCC(O)N1.[H]O[H].[H]O[H]
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	THU (dihydrate),NSC-112907 (dihydrate)
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	DNA/RNA Synthesis
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	284.26
Product Description	Tetrahydrouridine dihydrate (THU dihydrate) is potent inhibitor of cytidine deaminase (CDA), which competitively blocks the enzyme's active site more effectively than intrinsic cytidine.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Cell Cycle/DNA Damage
Clinical information	Phase 2

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HY-15345-5mg-safety-datasheet.pdf